[5] The ecoregion is in the transitional area between the Amazon Basin and Guayana forests, and has diverse flora.

[3] The Sierra de Chiribiquete is in the center of the region between the Apaporis and Yari rivers, with a maximum elevation of 840 metres (2,760 ft).

Some endemic species are Chiribiquete emerald (Chlorostilbon olivaresi), grey-legged tinamou (Crypturellus duidae) and mottle-faced tamarin (Saguinus inustus).

There are 13 primate species including Spix's night monkey (Aotus vociferans) and white-faced saki (Pithecia monachus).

[3] Other species include the golden-mantled tamarin (Saguinus tripartitus), jaguar (Panthera onca) and spectral bat (Vampyrum spectrum).

[5] 469 birds species have been recorded, including the endemic Chiribiquete emerald (Chlorostilbon olivaresi) and grey-legged tinamou (Crypturellus duidae).

Other birds include the plain-winged antwren (Myrmotherula behni), dusky spinetail (Synallaxis moesta), lemon-throated barbet (Eubucco richardsoni) and zone-tailed hawk (Buteo albonotatus).

[3] The forest is fairly intact and stable, although the 8,550 square kilometres (3,300 sq mi) Nukak National Natural Reserve is the only protected area in the region.

Colonists are moving down the Rio Negro clearing forest for small scale agriculture or cattle raising.