The original location of the high school was in the Pittsburgh neighborhood of Troy Hill, where it remained in operation for 75 years.

[9] On June 2, 2012, the Diocese of Pittsburgh held a groundbreaking ceremony in Cranberry Township to signify the start of the construction of Cardinal Wuerl North Catholic High School, slated to receive students in the fall of 2014.

The team has won numerous awards, and several students have been named Dean's List Finalists.

The marching band performs halftime shows at both away and home football games and participates in parades.

[17] In 2021, North Catholic’s football team reached the 3A WPIAL Championship, ultimately losing to Central Valley.