Pierre-Paul Guérin de Tencin (Grenoble, 22 August 1679[1] – 2 March 1758), French ecclesiastic, was archbishop of Embrun and Lyon, and a cardinal.

He remained at Rome as French chargé d'affaires, with the appointment in commendam of abbot of Trois-Fontaines to support him (1739–1753), until Benedict XIII, with whom he was on cordial terms of intimacy and very influential, consecrated him Archbishop of Embrun (26 June 1724).

He was overzealous in the persecution of the Jansenists, and, at the provincial synod which he held at Embrun from 16 August to 28 September 1727, he suspended Jean Soanen, Bishop of Senez, a prelate eighty years of age, who had appealed against the Bull Unigenitus.

[4] After the death in 1743 of André-Hercule Cardinal de Fleury, the prime minister to whom he owed much of his political advancement, his influence began to decrease.

The death of Claudine Guérin de Tencin, his salonist sister, in 1749 removed some of his political ambition, and in 1752 he retired to his see of Lyons.