Games between the two clubs see numerous visiting fans in either St. Louis's Busch Stadium or Chicago's Wrigley Field.

The teams' lone MLB playoff meeting occurred in the 2015 National League Division Series, which the Cubs won, 3–1.

On October 15, Browns manager Charles Comiskey pulled his team off the field in the 6th inning in protest of umpire Dave Sullivan's call.

Bob Caruthers pitched a one-hitter, and left fielder Tip O'Neill smacked two inside-the-park home runs.

With Jim McCormick and Jocko Flynn lame and John Clarkson tired‚ Chicago tried to use a minor league recruit in the pitcher's box‚ only to be refused by the Browns.

Pitching his fourth game in six days‚ Clarkson held St. Louis hitless for six innings as Chicago built a 3–0 lead.

In the 10th, Curt Welch scored on the "$15‚000 slide" after a wild pitch to win it in front of a fired-up St. Louis home crowd.

The Cardinals have won the World Series 11 times, the most of any National League team and second New York Yankees (27) in all of MLB.

Cubs' Slugger Hack Wilson had a combative streak and frequently initiated fights with opposing players and fans.

On June 22, 1928, a riot broke out in the ninth inning at Wrigley Field when Wilson jumped into the box seats to attack a heckling fan.

Sutter was at the forefront of the emergence of the closer in the late 1970s and early 1980s: a hard-throwing pitcher who typically came in just for the ninth inning and saved around 30 games a season.

However, in the ninth inning, Sandberg, not yet known for his power, slugged a home run to left field against the Cardinals' ace closer.

The Cardinals' Willie McGee (who had hit for the cycle that day) had already been named NBC's player of the game before Sandberg's first home run.

As NBC play-by-play man Bob Costas (who called the game with Tony Kubek) said when Sandberg hit that second home run, "Do you believe it?!"

In 1998, the teams were connected by the Mark McGwire-Sammy Sosa home run race, credited by many with revitalizing the sport following the players' strike which cancelled the 1994 World Series and the first part of the 1995 season.

In the first game, McGwire hit his record-tying 61st home run off pitcher Mike Morgan in the first inning as part of a 3–2 Cardinals victory.

In a show of sportsmanship, Sammy Sosa embraced and congratulated his rival and on-field opponent after McGwire rounded the bases.

Sosa dedicated each of his 66 home runs that season to the memory of Cubs (and former Cardinals) broadcaster Harry Caray, who died in February that year.

Lee was awarded both the Gold Glove and Silver Slugger as the best NL first baseman on both defense and offense, respectively.

In 2002, after Cardinals pitcher Darryl Kile was found dead in a Chicago hotel room, a game between the teams in Wrigley Field was postponed.

[12][14] Then in 2007, another Cardinals pitcher, Josh Hancock, was killed in a car crash while driving intoxicated, causing a game in St. Louis to be postponed.

[15][16][17] Former Cubs shortstop Ryan Theriot, who was acquired by the Cardinals on November 30, 2010, told a St. Louis radio station that he was "finally on the right side of the Cardinals–Cubs rivalry" and that he was happy to be with an organization that emphasized winning World Series championships instead of being "an afterthought".

The two clubs played each other in the postseason for the first time in the 2015 National League Division Series, as a result of the Cubs' 4–0 victory over the Pittsburgh Pirates in the NL Wild Card Game.

While the Cardinals were the westernmost team in the National League, the Cubs drew on the large numbers of Midwestern expatriates who either lived or vacationed in the West.

My friends, happily rooting for Stan Musial, Red Schoendienst, and other great Redbirds, grew up cheerfully convinced that the world is a benign place, so of course, they became liberals.

In order to establish Jason Bateman's character, Marty Byrde, as a Chicago native who moved to Lake Ozark, Missouri, the show writers included several references to the rivalry through the first season.

"[62] Many players have played for both teams, including Hall of Famer Rogers Hornsby, who holds several single season hitting records for both clubs.

Notably, Hall of Famer Lou Brock was traded from the Cubs to the Cardinals early in his career for pitcher Ernie Broglio.

Other Hall of Famers who played/managed with both clubs include Grover Cleveland Alexander, Clark Griffith, Burleigh Grimes, Bruce Sutter, Roger Bresnahan, Dizzy Dean, Dennis Eckersley, Rabbit Maranville, Hoyt Wilhelm, and Leo Durocher.

Coincidentally, Piniella and La Russa both grew up in Tampa and faced each other in the 1990 World Series as managers of the Cincinnati Reds and Oakland Athletics, respectively.