Carl Barton Huffaker (September 30, 1914 in Monticello, Kentucky – October 10, 1995 in Lafayette, California) was an American biologist, ecologist and agricultural entomologist.
After working as a medical entomologist in Colombia, Haiti, and the Dominican Republic he was recruited by Harry Scott Smith in 1946 to work as an assistant entomologist for the Division of Biological Control of the University of California.
Huffaker's first assignment was the control of Klamath weed, particularly the use of Chrysolina quadrigemina.
He published more than 200 scientific papers and edited and contributed to books "citation classics" in population ecology, biological control, and integrated pest management.
In 1994 he was awarded the Wolf Prize in Agriculture along with Perry L. Adkisson “for their contributions to the development and implementation of environmentally beneficial integrated pest management systems for the protection of agricultural crops”.