Bergstrom's work concerns the flow of information through biological and social networks,[6] as well as the ecology and evolution of pathogenic organisms, including the development of resistance.

[13] With Jevin West, he developed the popular course and website Calling Bullshit.

[14][15][16][17][18][19] His work has led to the identification of him as a resource to explain the dynamics of disinformation and misinformation,[20] in general.

In addition to evolutionary biology, Bergstrom's interests include the ranking of scientific journals.

[21] This and related work on open access earned him and his father, Ted Bergstrom, the SPARC Innovator Award in June 2007.