[3] He also claimed a silver medal at the 2007 European Union Amateur Boxing Championships in Dublin, losing to France's Khedafi Djelkhir in the final.

In June 2009, fought his first professional fight at the Olympia, Liverpool, in England and beat Sandor Szinavel with a second-round knock-out on a card that included Grzegorz Proksa and Ajose Olusegan.

In September 2010 he recorded an "electrifying" win over the Ukrainian Yuri Voronin in front of an Ulster Hall crowd which included Daniel Day-Lewis.

[7][8] Following his victory, Frampton described the super-bantamweight division as being "super-hot" and named Scott Quigg and Rendall Munroe as potential opponents.

Carl fought Australian Mark Quon as a replacement for Kiko Martinez on 10 September for the Commonwealth super-bantamweight title at the Odyssey Arena in Belfast winning by a fourth-round TKO stoppage.

[9] On 28 January 2012, he successfully defended his Commonwealth title against Kris Hughes in the York Hall, with the fight having to be stopped in the seventh round.

[11] Frampton then beat fellow unbeaten contender Raúl Hirales, Jr. (previously 16–0, 8 KO's) of Mexico by a unanimous decision and won the vacant IBF Inter-continental super-bantamweight title on the undercard of Carl Froch vs. Lucian Bute in Nottingham, UK.

[12] On 9 February 2013, Carl Frampton faced hard-punching Spaniard Kiko Martinez in front of 8,000 of his home fans in the Odyssey Arena in Belfast.

[15] On 4 April 2014 Frampton faced the Mexican Hugo Cazares at the Odyssey Arena in a final eliminator for Leo Santa Cruz's WBC super-bantamweight title.

In 2015, he was named Britain's Coolest Man by ZOO Magazine beating the likes of David Beckham, Tom Hardy and Ed Sheeran to get the award.

[23] In December 2014, it was announced that Frampton would make his first defence of his title on 28 February 2015 against American Chris Avalos (25–2, 19 KOs) at the Odyssey Arena in Belfast, Northern Ireland.

[25][26] Frampton defended his world title against Avalos in a one-sided, fifth-round knockout, where referee Foster waved off the contest at 1 minute, 33 seconds.

[29] It was announced that Frampton would make a second defence of his IBF World title on 18 July at the Don Haskins Convention Center, El Paso, Texas, against 22-year-old Alejandro González Jr. live on ITV.

[32] On 27 October 2015, the long-awaited fight between Frampton and undefeated WBA (Regular) super-bantamweight champion Scott Quigg (31–0–2, 23 KOs) was being discussed according to both sides.

It was believed that Frampton aligning with boxing manager and advisor Al Haymon may have helped get the deal across the line, due to the close relationship between him and Quigg's promoter Eddie Hearn.

[35][36] On 2 November, the fight was officially announced to take place at the Phones4U Arena in Manchester on 27 February 2016, billed for the IBF and WBA super-bantamweight titles, on Sky Sports Box-Office.

The fight would be broadcast live, ahead of the Showtime Championship Boxing telecast of Léo Santa Cruz vs. Kiko Martinez.

[41][42] On the other hand, the WBA Championships Committee announced Rigondeaux as 'champion in recess', due to his managerial and promotional issues and not having a fight scheduled.

[60][61] Frampton moved up a weight class to fight undefeated Mexican Léo Santa Cruz (32–0–1, 22 KO's) for the WBA (Super) featherweight title at the Barclays Centre in New York City on 30 July 2016.

[62] In a potential fight of the year candidate, Frampton became the first two-division world champion in the history of Northern Ireland as he dethroned Santa Cruz via a 12-round majority decision win before a crowd of 9,062.

[77][78] Cyclone Promotions confirmed that Frampton would fight 23-year-old Mexican boxer Andrés Gutiérrez (35–1–1, 25 KOs) at the SSE Arena in Belfast in a WBC eliminator.

[81] Frampton apologised to his fans for the turn of events[82] "After a long training camp of intense preparation and trying to make weight, I was disappointed that I came in 1lb over the featherweight limit today.

I'd like to apologise to the fans that have got involved and shown incredible support throughout this frantic fight week, and to those that will be cheering me onto victory on Saturday night.

I would have been happy to be doing twelve rounds but speaking to my team after the bad year I’ve had and the long layoff they thought it was only fair to come back with a ten rounder before we target the big names.”[95] This would mark Frampton's first fight in Belfast since February 2015, when he made his first defence of the IBF super-bantamweight title.

[99][100] In December 2017, Frank Warren announced Frampton would next fight on 7 April 2018 in Belfast with former four-weight world champion Nonito Donaire (38–4, 24 KOs) as a potential opponent.

[102] On 21 December, the fight was officially announced by Frank Warren via the BoxNation Facebook page to take place on 21 April 2018 at the SSE Arena, Belfast.

In the second half of the fight, Donaire had more success, hurting Frampton on a number of occasions, landing a hard left hook in round eleven.

However, Frampton was forced to withdraw from the fight after a large concrete ornament accidentally struck his left hand, fracturing his metacarpal.

In the post-fight interview, when asked about a potential match up with WBO junior-lightweight champion Jamel Herring, who was sitting ringside, Frampton said, "I know he's a champ.

After Vardanyan was unable to secure a visa to enter the UK, former British featherweight title challenger Darren Traynor was brought in as a late replacement.