He made his breakthrough with Lierse in first division and won the Belgian Cup in 1999, beating Standard Liège in the final with 3–1.

In his second season at Germinal Beerschot, he won the cup in the final against Club Brugge, then champions of Belgium.

[2] In the summer of 2005, Stoke City manager Johan Boskamp snapped him up for an undisclosed fee.

During the January 2007 transfer window, he was linked with a return to Belgium, with Club Brugge reportedly interested in him.

He was also praised for his versatility, as he operated as a winger or a central midfielder on occasions in the latter stages of the season.

It was feared that Hoefkens had broken a bone in his foot in a Euro 2008 qualifier against Portugal however a scan revealed that there was no damage.

[6] Hoefkens made his Albion debut in a 2–1 defeat away at Burnley on the opening day of the 2007–08 season.

[8] He is known by his West Brom teammates as "Wolverine", due to his resemblance to the comic book hero from X-Men.

[10] On 25 August 2009, Club Brugge signed the former West Bromwich Albion's Belgian right-back on a two-year deal.

In August 2015, after his release from Oostende, Hoefkens signed for Gibraltar Premier Division side Manchester 62, who beat off competition from reigning champions Lincoln Red Imps for his signature.