[1] Simón was born 22 December 1986 in Barcelona[2] and spent her youth in the Catalan village of Les Planes d'Hostoles.

[3] By the age of six, her parents died of AIDS so she had to live with her uncle and his family in Garrotxa in northern Catalonia.

In 2009, Simón graduated from studying film science at the Universitat Autònoma de Barcelona.

[6] The plot revolves around a young girl and her reaction to and ways of handling her parents' sudden death.

[13] Simón's sophomore feature Alcarràs (2022) won the Golden Bear at the seventy-second edition of the Berlinale, becoming the first Catalan-language film to do so.