Carlo De Simone (4 March 1885 – 1951) was an officer in the Italian Army during World War II.

However, during the Italian invasion of British Somaliland, De Simone commanded General Guglielmo Nasi's main "center" column.

De Simone's command in Italian Somaliland included the reinforced Harar Division (XIII Colonial Brigade, XIV Colonial Brigade, and XV Colonial Brigade - amounting to eleven infantry battalions, fourteen batteries of artillery, 21 howitzer batteries, half a company of M11/39 medium tanks, a squadron of 12 L3/35 light tanks, and an armored car company.

His forces captured Berbera from the British on August 19, 1940, solidifying Italian control over Somaliland until Britain's Operation Appearance.

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