Born in Brescia, he holds a bachelor's degree (summa cum laude) in Philosophy from the University of Genoa, a M.A.

[3] In the years 2003–04, Lottieri taught Philosophy of Social Sciences at Ca' Foscari University of Venice, and in 2011 became visiting professor at Aix-en-Provence.

Fellow of many institutions,[4] he is the Director of Political Theory department of the Istituto Bruno Leoni (IBL), based in Turin.

[5] Lottieri's research develops a radical American-style libertarianism combining a strong emphasis on the inviolability of other people (marked by the influence of Emmanuel Lévinas) and a realistic approach to the modern state, largely influenced by Italian elitist school, Carl Schmitt's scholarship, and public choice and Austrian School economists.

"[6] His last book emphasizes the historic features of the modern state, suggesting to libertarian scholars to understand the cultural and even theological implications of the struggle between the rulers and the ruled.