Carlos Antonio Mendoza Soto (31 October 1856, in Panama City – 13 February 1916) was a Panamanian politician who served in 1908 and 1909 as the second presidential designate in the government of José Domingo de Obaldía.

After the death of the first presidential designate José Agustín Arango in 1909 he was first in line to the presidency.

Mendoza was elected as the third presidential designate by the National Assembly for the 1904–1906 term.

Río Piedras, Puerto Rico: Editorial Plaza Mayor.

(1999) • Mellander, Gustavo A., The United States in Panamanian Politics: The Intriguing Formative Years."