His father was a football player and a member of the Philippine national team which competed and won medals at the Far Eastern Championship Games.

He was about to enroll at the University of Santo Tomas, but this also did not materialize after Fely Fajardo (older brother of Gabby), coach of the San Beda Red Lions, recruited him.

In the NCAA cage wars for the coveted Zamora Trophy in the 1950s, San Beda lost its title bid when Loyzaga did not see action due to scholastic reasons.

He was allowed to play for that one year specifically for the Red Lions to capture the Zamora Cup, the prize for the team that had three NCAA championships.

[5][6] Loyzaga joined the fabled YCO Painters in 1954 after powering PRATRA, and its successor team, PRISCO (Price Stabilization Corporation), to the National Open championship in 1950 and 1953, respectively.

After retiring as a player in 1964, he became the head coach of YCO and the Manila Bank Golden Bankers in the MICAA; and the UST Glowing Goldies in the UAAP.

[11] Loyzaga was married to Vicky Cuerva on 21 May 1957; the couple's children include basketball players Chito and Joey, Princess, and actresses Bing and Teresa.

[16][17][18] As a posthumous commemoration, the San Beda College officially retired the #14 jersey used by Loyzaga during the opening ceremonies of the NCAA Season 92 basketball tournament on June 25, 2016, at the Mall of Asia Arena.