He ran in the 2016 New Progressive Party primary to be Puerto Rico's Resident Commissioner as Pedro Pierluisi's ballot running mate, but lost by over 70% of the vote to state representative Jenniffer Gonzalez.
Carlos Ignacio Pesquera Morales graduated from High School while attending Nuestra Señora de Belén.
Pesquera was the Secretary of the Department of Transportation and Public Works of Puerto Rico under Pedro Rosselló's first and second terms as Governor (1993–1999).
As Secretary of Transportation, he is credited as the driving force behind the $2 billion Tren Urbano (Urban Train), the Superaqueduct that has resolved metropolitan San Juan's water rationing problems, numerous road construction projects and the construction of the José Miguel Agrelot Coliseum in San Juan.
In January 2007, Governor Aníbal Acevedo Vilá nominated him to be part of the Board of Regents of the University of Puerto Rico.