Fisk is best known for his game-winning home run in the 12th inning of Game 6 of the 1975 World Series, during which he memorably waved his arms hoping for the batted ball to remain fair.

Because his family is from New Hampshire, he insisted that the organization remove from his plaque in the Red Sox Hall of Fame its characterization of him as a Vermont native.

[3][4][7] In 1967, Fisk played briefly for the Red Sox team in the Florida Instructional League, hitting .195 with 0 HR and 0 RBI in 47 at bats.

He then played for the Class AA Pittsfield Red Sox of the Eastern League, where he hit .243 with 10 HR and 41 RBI in 97 games and 309 at-bats.

[8] Fisk played for the Class AAA Louisville Colonels of the International League in 1971, hitting .263 with 10 HR and 43 RBI in 93 games, before being called up to the Boston Red Sox.

"Johnson taught me to think about all the important facets of the catcher's role, the things that help pitchers in various ways and those that let your teammates know you want to win," he told an interviewer in 1973.

In addition, he led the American League with nine triples (tied with Oakland's Joe Rudi), and was the last catcher to lead the AL in this statistical category.

In Game 3 of the World Series at Riverfront Stadium, Fisk led off the second inning with a solo home run off Cincinnati starter Gary Nolan.

In the bottom of the 10th inning, Reds pinch-hitter Ed Armbrister collided with Fisk at home plate while starting to run out a sacrifice bunt, leading to a wild throw by Fisk to second base that allowed Cesar Geronimo to reach third base and eventually score the winning run.

[13] Leading off the bottom of the 12th inning of Game 6 at Fenway Park, Fisk hit a pitch off of Cincinnati relief pitcher Pat Darcy that went down the left-field line and appeared to be heading into foul territory.

The image of Fisk jumping and waving the ball fair as he made his way to first base is considered by many to be one of baseball's greatest moments.

The ball struck the foul pole for a home run, giving the Red Sox a 7–6 win and forcing a seventh and deciding game of the Fall Classic.

"The celebration of that moment has made me realize how popular baseball is and how it affects people's lives," Fisk told The Boston Globe.

Fisk chose to wear 72 with the White Sox explaining that he had won American League Rookie of the Year in 1972; his son Carson had been born in 1972; and 72 was the reverse of 27.

His .289 batting average, 26 home runs, and 86 RBI, as well as his leadership on the young team, helped him to finish third in the MVP voting (behind Baltimore teammates Cal Ripken Jr. and Eddie Murray).

In his Hall of Fame induction speech, Fisk credited White Sox strength and conditioning coach Phil Claussen for his turnaround.

[25] On August 4, 1985, Fisk caught all nine innings of Tom Seaver's complete game 300th career victory, which was played in Yankee Stadium.

[26] After the 1985 season, the White Sox came close to trading Fisk to the New York Yankees for designated hitter Don Baylor.

The potential deal was complicated in that the White Sox would have to re-sign Fisk, a free agent, and that both players would have to agree to the trade.

During spring training in 1986, the Yankees traded Baylor to the Boston Red Sox for designated hitter Mike Easler.

[31] Six days after breaking Bob Boone's all-time games caught record, Fisk was abruptly released by the Chicago White Sox at age 45.

[32] To add insult to injury, Fisk was thrown out of the White Sox clubhouse later that season when he stopped by to wish his teammates good luck in the playoffs.

In thirteen seasons with the White Sox, Fisk was selected to four All-Star games and batted .257 with 214 home runs and 762 RBI.

One particular incident that typified their feud, and the Yankees – Red Sox rivalry in general, occurred on August 1, 1973, at Fenway Park.

"[35] In another incident typifying the Yankees-Red Sox rivalry, Fisk was involved in an altercation with Lou Piniella during a May 20, 1976, game at Yankee Stadium.

After order appeared to be restored, Red Sox pitcher Bill Lee and Yankees third baseman Graig Nettles began exchanging words and punches, igniting the brawl anew.

[citation needed] Footage of Fisk's home run appears in the 1997 film Good Will Hunting, during a scene in which the character Sean Maguire (Robin Williams) tells the story of how he met his wife on the same day the game occurred.

ET early on the morning of October 22, 1975, when Fisk drove a 1–0 fastball from Cincinnati right-hander Pat Darcy high into the air, heading down the left-field line.

It joined similar statues depicting Charles Comiskey, Frank Thomas and Minnie Miñoso and eventually Luis Aparicio, Nellie Fox, Billy Pierce and Harold Baines.

[59][60] Fisk's daughter, Courtney, helped lead Lockport Township High School to the Illinois State Volleyball Championship.