Myers attended Los Angeles High School but left after D. W. Griffith gave her bit part in the film Intolerance (1916), for which her father was an unpaid consultant.

Her most popular film from this period—which does not feature her in a vamp role—is probably the romantic comedy All Night, opposite Rudolph Valentino, who was then a little-known actor.

By 1924, she was working for Metro-Goldwyn-Mayer, making such films as Broadway After Dark, which also starred Adolphe Menjou, Norma Shearer, and Anna Q. Nilsson.

This film was a boost to her career, and she appeared in major roles throughout the 1920s, including Tell It to the Marines in 1926 with Lon Chaney, Sr., William Haines, and Eleanor Boardman.

Myers had a fairly successful sound career, mostly in supporting roles, perhaps due to her image as a vamp rather than as a sympathetic heroine.

Amongst her popular sound films are Svengali (1931) and The Mad Genius (1931), both with John Barrymore and Marian Marsh, and a small role in 1944's The Conspirators, which featured Paul Henreid, Peter Lorre, and Sydney Greenstreet.

Grandson literary agent/manager John Ufland (born 1962)Myers and Blum purchased Gloria Swanson's Sunset Boulevard home.