The third film was used as a test for a special Texas Instruments digital projector which can project polarized 3D, which does not require the red-blue lenses, later reused for The Adventures of Sharkboy and Lavagirl in 3-D (2005).

[5][6] After retiring from espionage for ten years, Gregorio and Ingrid (Antonio Banderas and Carla Gugino) are pulled back into duty for their important assignment despite the fact they were out of practice, and were captured.

Their two children, Carmen and Juni (Alexa Vega and Daryl Sabara), stay with their uncle Felix Gumm (Cheech Marin) and discover the truth of their parents' past, which they had neglected to tell them because they were afraid that if they knew, they would picture danger at every corner; and decide to rescue them.

Together, Carmen and Juni thwart the plan of Floop's notorious second in-command Alexander Minion (Tony Shalhoub) to develop an army of androids resembling young children (including Carmen and Juni themselves) for a mastermind named Mr. Lisp (Robert Patrick) and his partner Ms. Gradenko (Teri Hatcher).

As agents of the OSS, Carmen and Juni try to save the daughter (Taylor Momsen) of the President of the United States (Christopher McDonald) while facing a particularly hard competition with Gary and Gerti Giggles (Matt O'Leary and Emily Osment), the two children of a double-dealing agent Donnagon Giggles (Mike Judge), whom Carmen and Juni helped to rescue them from the first film.

Juni loses his spot for the best spy kid of the year award, while Donnagon plans to steal the transmooker to take over the world.

Juni is offered his job back, but in order to take a break from the OSS, he retires to start his own private eye agency.

Marissa (Jessica Alba), a retired spy, is thrown back into the action along with her two stepchildren, Rebecca and Cecil (Rowan Blanchard and Mason Cook), when a maniacal Timekeeper (Jeremy Piven) attempts to take over the world.

The fifth installment titled Spy Kids: Armageddon, served as a relaunch of the franchise, involves a plot that centers on a multicultural family.

[7] Gina Rodriguez, Zachary Levi, Everly Carganilla and Connor Esterson were set to star,[11] along with Billy Magnussen[12] and D. J.

[18] In September 2023, Rodriguez confirmed that Netflix intends to develop additional Spy Kids movies,[18] with the filmmaker expressing hope to begin production on a sequel the following year.

In 2002, KD Novelties made a personalized children's book based on Spy Kids 2: The Island of Lost Dreams.

[38] Between 2003 and 2004, Disney-Hyperion released ten novels of a book series titled Spy Kids Adventures, written by Elizabeth Lenhard.