In live-action, the character has been portrayed in film by Tom Wilkinson in Batman Begins (2005) and in television by John Doman in Gotham (2014–2017).

Carmine Falcone made his debut in the four-part story Batman: Year One written by Frank Miller and David Mazzucchelli in 1987.

Lastly, his elder son Mario's deportation to Sicily, physical appearance, and desire to legitimize the Falcone family are all traits shared with Michael Corleone.

[2] In a flashback in The Long Halloween, gangster Vincent Falcone brings his badly wounded son, Carmine, who had been shot several times by his rival, Luigi Maroni, to Thomas Wayne.

Years later at Thomas and Martha Wayne's funeral, Carmine Falcone, now part of his father's crime family, tells Bruce that he can always ask a favor of him should he need it.

When Gordon and District Attorney Harvey Dent's investigations start threatening his power, Falcone orders an unsuccessful hit on Johnny out of fear that he might talk.

[4] Falcone's son Alberto, presumed to have been the victim of the killer, confesses that he committed the Holiday killings in an attempt to be accepted into the family business.

Carmine Falcone appears in the second issue of Batman Eternal as a former mobster determined to reclaim his empire after Commissioner Gordon is framed for mass murder.

[7] Falcone is unaware of the larger plot against Batman, and was informed that he would have a chance to strike by an anonymous letter sent to him by the true mastermind.