The station was built in the corridor of the former 1,000 mm (3 ft 3+3⁄8 in) gauge Porto to Póvoa and Famalicão railway line that operated into the Porto-Trindade terminus.

These lines dated from the opening of that terminus in 1938, and were closed in 2001 to enable the construction of the Metro.

[1][2] The new station was inaugurated on 7 December 2002 and commercial services started on 1 January 2003.

Like other stations in the common section of lines A, B, C, E and F, Carolina Michaëlis sees a very frequent service, with up to 21 trains per hour in both directions.

It is partly covered by the Carolina Michaëlis de Vasconcelos stairway, which links the two streets, and has two through tracks served by two side platforms.