Carolina del Príncipe is a town and municipality in the Colombian department of Antioquia, located 105 km north of Medellín, with an altitude of 1,807 m above sea level.

Carolina is a small town of well laid-out cobblestone streets, containing many houses with antique handmade wooden balconies.

The municipal total area covers some 118 km2, with a mountainous territory corresponding to the central spine of the Andes and bounded by the Concepción or Minavieja, Guadalupe, San Pablo and Tenche rivers.

It has a population of 666 inhabitants and its economy is based on animal husbandry (dairy and meat) and the cultivation of maize, sugar cane, rice, cocoa, and corn.

The name was chosen in honor of Carlos IV of Spain, then the prince in line to be heir of his father's throne.