Caroline Louise of Waldeck and Pyrmont (14 August 1748 – 18 August 1782), was a Princess of Waldeck and Pyrmont by birth and Duchess of Courland by marriage.

Karoline Luise was born as the eldest daughter of Karl August, Prince of Waldeck and Pyrmont, and his wife Christiane Henriette, Countess Palatine of Zweibrücken-Birkenfeld-Bischweiler.

She married the Peter von Biron, Duke of Courland, on 15 October 1765.

The relationship between Caroline and Peter was unhappy, and evidently, he abused her while drunk.

The union produced only one son, who was stillborn on 16 November 1766.