During the relocation of its flagship Carl Vinson to its new home base in San Diego, California, it supported Operation Unified Response, providing humanitarian assistance following the 2010 Haiti earthquake.

This naval exercise involved the embarked Air Group 74 conducting flight operations in Davis Straits between Labrador and Greenland.

[10][11] Subsequently, Admiral Cassady commanded Task Group 125.4, consisting of the carrier Franklin D. Roosevelt; the cruiser Little Rock; and the destroyers New, Cone, and Corry, which paid a highly publicized port visit to Piraeus, Greece, in September 1946.

According to James Chace, the deployment of Task Group 125.4 "symbolized" American resolve against that Soviet pressure, marking the true beginning of the Cold War.

[16] Despite being headquartered at North Island, it was responsible for the Midway, which with Carrier Air Wing Five aboard had moved to United States Fleet Activities Yokosuka, Japan, on 5 October 1973.

[22] On 15 January, the Carl Vinson arrived off the coast of Port-au-Prince (pictured) to provide humanitarian aid, with its trained personnel, emergency relief supplies, and 19 helicopters on deck.

[29] In March 2010, during her transit around South America, the carrier strike group participated in Southern Seas 2010 naval maneuvers with the Brazilian, Uruguayan, and Argentine navies.

[34] On 5 May 2011, as part of NATO's counter-piracy Operation Ocean Shield, Vinson, Bunker Hill, and the Turkish frigate Giresun responded to a distress call from the Panamanian-flagged, Chinese-owned bulk carrier Full City.

An Indian Navy Tu-142 maritime patrol aircraft located the Full City, and while Giresun boarded the merchant vessel, Bunker Hill and its embarked HS-49 helicopters intercepted a dhow believed to be the 'mothership' for the pirate attack.

[60] On 19 January 2012, while serving as the flagship of Combined Task Force 151, the destroyer Halsey and its HSL-49 helicopter detachment responded to a distress call from M/V Albrouj, a Yemeni dhow en route to Somalia from Yemen.

[66][68] On 5 July 2012, the carrier Carl Vinson began a planned incremental availability (PIA) overhaul to undergo major maintenance and modernization, with a scheduled completion date of 1 February 2013.

[75] Between 2–14 May 2013, the Carl Vinson and Carrier Air Wing Seventeen completed their Underway for Tailored Ship's Training Availability (TSTA) pre-deployment exercises.

[76] On 22 March 2012, the cruiser Bunker Hill began its five-month Drydocking Selected Restricted Availability (DSRA) overhaul at the BAE Systems San Diego Ship Repair facility.

[71] The destroyer Gridley began its selected restricted availability (SRA) yard at BAE Systems San Diego Ship Repair facility on 26 June 2013.

A surface warfare officer, Admiral Grady commanded Destroyer Squadron 22 during its deployment to the U.S. Fifth Fleet with Carrier Strike Group Two.

On 10 February 2014, Carrier Strike Group One returned to Naval Air Station North Island, California, completing the TSTA/FEP phase of its pre-deployment exercises.

[86] On 2 June 2014, the carrier strike group successfully completed its Composite Training Unit Exercise (COMPTUEX) off the coast of Southern California.

JTFEX is an integrated battle force exercise designed to test the capabilities of carrier strike groups operating within a joint environment.

[91] On 12 September 2014, two F/A-18C Hornet single-seat strike fighters collided and crashed approximately 250 nautical miles (460 km; 290 mi) west of Wake Island.

[7] In support of Operation Inherent Resolve, the strike group flew 12,300 sorties, including 2,383 combat missions; landed more than 9,220 aircraft; and dropped 869 precision guided munitions for a total of more than 500,000 lb (230,000 kg) of ordnance delivered on target.

[98] On 1 April 2015, the Sterret carried out a boarding of the Panamanian-flagged merchant ship Saisaban in support of the U.N.-authorized arms embargo against Houthi forces in Yemen.

[5] After Carrier Strike Group paid its final 2015 port call at Naval Station Pearl Harbor, a MH-60S Seahawk helicopter from squadron HS-15 rendered assistance to a mariner, who had been alone at sea for more than 30 days aboard his 35-foot sailboat, in the Pacific Ocean more than 400 nautical miles (740 km; 460 mi) off the coast of Honolulu on 31 May 2015.

[4][7][101] On 4 June 2015, Carrier Strike Group One arrived back at Naval Base Point Loma, California, concluding its 10-month deployment to the U.S. Fifth and Seventh fleets.

[109] During the first half of April 2017, the strike group was reportedly ordered towards the Korean Peninsula amid growing concerns about North Korea's ballistic missile program.

[110] The Carl Vinson and its escorts were 3,500 miles (5,600 km) away however, undertaking joint exercises with the Royal Australian Navy in the Indian Ocean south off Singapore.

[111] In late April, the Strike Group was joined by two Japan Maritime Self-Defense Force destroyers; the JDS Ashigara and the JS Samidare as they transited the Philippine Sea en route to the Korean peninsula.

[113] Later that month, the Strike Group was joined by the USS Ronald Reagan which had just completed a period of Selected Restricted Availability maintenance.

In early June, the USS Ronald Reagan's Carrier Strike Group 5 joined CSG 1 in the Sea of Japan, along with the JMSDF vessels Ashigara and JDS Hyūga.