In the National Football League (NFL), Emmitt Smith holds the record for the most career carries, with 4,409.
[1] The current leader in yards-per-carry in NFL history with at least 750 carries is former quarterback Michael Vick.
[2] The statistical treatment of yardage lost on sacks differs between the NCAA and NFL.
Under NCAA rules, sacks count as rushing yards for both the player and his team.
[3] In the NFL, sacks are not counted in the quarterback's passing or rushing yardage, but are counted as part of the team's passing yardage.