He played in the National Hockey League (NHL) with the Chicago Blackhawks, Nashville Predators, St. Louis Blues, Buffalo Sabres and the Arizona Coyotes.

[9] He eventually became the Predators' starting goalie for most of the 2013–14 NHL season and posted a 20–11–4 record after Pekka Rinne suffered a hip infection.

[10] By December, Hutton compiled a 3-0-0 record with a 1.33 goals-against average and .960 save percentage to earn the NHL Third Star of the Week.

[10] In his final year with the Predators, Hutton was the teams' 2016 Bill Masterton Memorial Trophy nominee as a "player who best exemplifies the qualities of perseverance, sportsmanship, and dedication to hockey.

"[12] After three seasons with the Predators as the backup to Rinne, Hutton left as a free agent to sign a two-year contract with the St. Louis Blues on July 1, 2016.

[13] Prior to the start of the season, Hutton earned praise from head coach Ken Hitchcock who called him "one of the best players during training camp.

[17] Later that month, Hutton earned his fifth career NHL shutout after making 23 saves in a 4–0 win against the San Jose Sharks on January 15.

[21] As a result of his play, Hutton helped the Blues move into third place in the Central Division and qualify for the 2017 Stanley Cup playoffs.

[23] Having concluded his two-year deal with the Blues, Hutton agreed to a three-year, $8.25 million contract with the Buffalo Sabres on July 1, 2018.

[26] He returned as the starter for the Sabres by November and helped them win four consecutive regular season games for the first time since December 2014.

[42] After a largely disappointing tenure with the Sabres organization, Hutton left as a free agent and was signed to a one-year, league-minimum $750,000 contract with the Arizona Coyotes on July 28, 2021.

[43] On the same day as his reassignment to the Roadrunners, Hutton was traded by the Coyotes to the Toronto Maple Leafs in exchange for future considerations.