The Casa Grande Hotel is a historic hotel located at the intersection of 3rd Street and historic U.S. Route 66 in downtown Elk City, Oklahoma.

The hotel opened in 1928, shortly after Route 66 was designated, to lodge the growing number of travelers on the highway.

Architects Hawk and Parr designed the four-story building in the Spanish Eclectic style; their design features arched windows and doors and stone ornamentation along the arches.

[2] The hotel was added to the National Register of Historic Places on February 23, 1995.

This article about a property in Oklahoma on the National Register of Historic Places is a stub.