Bandleaders who played Casa Loma include Louis Armstrong, Count Basie, Jimmy Dorsey, Tommy Dorsey, Benny Goodman, Harry James (with Frank Sinatra in 1939), Herbie Kay, Stan Kenton, Glenn Miller, Freddy Nagel, Artie Shaw, Lawrence Welk, and Frankie Yankovic.

Other performers who stopped at Casa Loma are Steve Allen, Tony Bennett, Bill Haley and the Comets, Bing Crosby, Rita Hayworth, Jerry Lee Lewis, Mickey Rooney, Tom and Dick Smothers, and Andy Williams.

It reopened later that year with a major improvement: a 5,000 square foot "floating" dance floor consisting of maple on top of an inch of rubber.

Lessons in ballroom, waltz, fox trot, tango, Latin and swing dancing often take place before the live music begins.

[3] The bandstand television program St. Louis Hop, hosted by Russ Carter, was filmed at Casa Loma Ballroom for part of its run.