[4] The house was built in 1911 by Alfredo Weichers,[5][note 1] for Juan Eugenio Serrallés Pérez and his wife Rosa María Sánchez.

The location of the house, together with its historic significance, courtyard, and architectural details, make it unique among other Puerto Rico homes.

"[9] Culturally, the building is important because it was the downtown residence of one of the wealthiest families in 19th-century Puerto Rico, and one that so much influenced its economy.

The original hill-top residence of the family was Castillo Serralles, today a historic structure listed in the NRHP.

The back of the property contains a spacious finished private yard, complete with a Don Q bar area, where—no doubt—guests were gracefully entertained in bygone years.