Cascade is an urban neighborhood abutting Downtown Seattle, Washington, United States, located adjacent to South Lake Union.

[2] Historic structures in Cascade Neighborhood include St Spiridon's Orthodox Cathedral, Immanuel Lutheran Church, and several defunct laundry blocks.

In 2007, a development named Alley24 was built around the New Richmond Laundry Building, a City of Seattle Landmark located between John and Thomas Streets and Yale and Pontius Avenues North.

She and her husband, Rezius Pontius, lived in the neighborhood by 1885, and by 1889 had built a Queen Anne style mansion, designed by John Parkinson, along Denny Way near what is now Yale Avenue.

[7] Cascade businesses in this era included sawmills, shingle mills, and boat yards along the lake, as well as cabinetry and furniture shops, grocery stores, laundries, and boarding houses.

[16] The decline of the depression years was briefly arrested by World War II, as the U.S. Navy built a reserve center on the site of David Denny's former mill, just west of Cascade and Kenworth expanded a factory on Mercer Street.

[7] Controversy ensued over whether or not to repair the school, but it was ultimately demolished since local businesses led by the Seattle Times desired an increasingly industrial rather than residential character neighborhood.

[7] The year 1949 also saw the first seeds of the "new" Cascade Neighborhood that would emerge almost half a century later: the Washington Teachers Credit Union was established, with quarters on Eastlake Avenue.

It would become the Washington School Employees Credit Union (1963), and eventually part of PEMCO Financial Services, still based in the Cascade Neighborhood as of 2008.

[7] (One building they purchased was, for a time, operated as the Seattle Concert Theater, but even that was "hastily razed" in the early 1980s to "head off a landmarks designation".

[7] In the early 1970s, activists including a University of Washington student named Frank Chopp began the Cascade Shelter Project, setting up geodesic domes on vacant lots to live in.

The northwest corner of the neighborhood became the campus of the Fred Hutchinson Cancer Research Center[7] and at the north tip of Cascade, the old City Light Steam Plant (a decommissioned electrical generation facility) became the headquarters of Zymogenetics.

Although a proposal to transform a north–south corridor just west of Cascade into a 74-acre (30 ha) park was twice defeated by the voters (in 1995 and in 1996), gentrification continued apace, largely driven by tech billionaire and developer Paul Allen's Vulcan Northwest group.

During most of their time in Cascade, they lived in the former Rodgers Tile Company building at 117-121 Yale Ave. N, later the 911 Contemporary Arts Center and now the Feathered Friends outdoor equipment shop.

Still, as late as 1937, the Fairview-Stewart Improvement Club was protested that the Cascade School was old and out of date, itself not worth preserving, and that the increasingly industrial and commercial neighborhood did not need a playfield.

A 1971 renovation included a mural on the retaining wall, funded by the Seattle Arts Commission and designed by Mike Love and George Shayler.

In addition, the surviving portion of the East Republican Street Stairway that once connected Cascade to Capitol Hill is a designated Seattle landmark.