Unlike a number of similar podcasts, the series is fully scripted and narrated, while relying primarily on original police or mass-media documents, eyewitness accounts, and interview or public announcement recordings.

Casefile first aired on 9 January 2016[3] and was conceived by an anonymous Australian host who started producing the show in 2015 in his spare room.

[5] According to several sources, the host remains anonymous because he wants the show to focus primarily on the stories, facts, and the questions raised.

[5][6][7] In its current format, the 2024 Casefile team consists of the host/narrator, two composers, a creative director, a digital media/designer, and three researcher/writers (and a producer for the Portuguese version).

One episode, Case 55 (Simone Strobel, released 15 July 2017), was removed due to legal issues, although general details of the podcast itself are still publicly available.

[4][5][15][16][17] One early review focussed on the differences to similar shows noticeable in the production, such as its sombre music and limited host editorialising, while also avoiding the use of primary materials by simply replaying news clips, emergency calls, and interviews.

[24] Since 2016, the show has received numerous awards: Each case includes a corresponding page on the Casefile Presents official homepage, which details information such as special thank-yous, official support phone numbers, and websites (for Australia, the UK, the US, Canada and New Zealand), other credits, and resources (such as books, websites, videos, documents, articles, maps, wanted posters, and suspect sketches).

Titled Casefile: Truth & Deception Board Game[37] players, acting as private detectives, try to solve the murder mystery of a businessman.