He played in Major League Baseball (MLB) for the Toronto Blue Jays, Minnesota Twins, Baltimore Orioles, Cleveland Indians, and Los Angeles Dodgers.

[3] Blake was selected by the Toronto Blue Jays in the seventh round (189th overall) of the 1996 Major League Baseball draft.

[5] Blake made his major league debut on August 14, 1999, against the Oakland Athletics at third base, and finished the game 0-for-3.

[9] On May 23, 2000, the Minnesota Twins claimed Blake off waivers and assigned him to the Triple-A Salt Lake Buzz.

[9] Blake spent the majority of the season with Triple-A Edmonton, batting .309 with 19 home runs and 58 RBI in 126 games.

He led the team in games played (152), hits (143), and doubles (35) while compiling career highs in every offensive category.

He started the season strong, batting .304 with 10 home runs and 36 RBI through June 15, when it was announced that he would be placed on the disabled list with a left oblique strain.

[23] As the Indians drove for a playoff spot, Blake hit a walk-off home run against the Kansas City Royals on September 14.

[9] The Indians won the American League Central, marking Blake's first time appearing in the postseason.

In Game 1 of the 2007 American League Division Series, Blake hit a two-run double off New York Yankees pitcher Ross Ohlendorf, helping Cleveland to a decisive 12–3 win.

[9] On July 26, 2008, Blake was traded from the Indians to the Los Angeles Dodgers for minor league players Carlos Santana and Jon Meloan.

[9][33] Blake hit just .167 with 2 RBI in the 2009 postseason, including a .105 mark in the 2009 National League Championship Series, which the Dodgers lost again in five games to the Phillies.

[9] Due to various injuries, Blake was only able to appear in 63 games for the Dodgers in 2011, hitting .252 with only four home runs (his lowest total since 2002) with 26 RBI.

[9] On September 1, he decided to undergo season-ending surgery on his neck to relieve the pain from a pinched nerve that had bothered him all season.

[34] On October 4, 2011, the Dodgers declined Blake's 2012 option, instead paying him a buyout of $1.25 million and making him a free agent.

[38] Blake splits time between Indianola, Iowa and Los Angeles, California with his wife, four daughters and a son.