Born 24 January 1980 in Nambour, Queensland, McGuire was playing junior league for Caloundra Sharks & Kawana Dolphins.

He then attended Caloundra State High QSSRL in 1997 when he was selected for the Australian Schoolboys rugby league team.

McGuire played from the interchange bench in the 2006 NRL Grand Final victory over Melbourne at Telstra Stadium.

McGuire missed the Broncos' 2007 World Club Challenge appearance due to his move to France to play in the Super League for Catalans Dragons.

[5] A pectoral muscle injury during the 2012 NRL season put the remainder of McGuire's playing career in doubt.