He joined Hapoel Eilat in 2020 and was named as the Israeli League MVP in 2021, but missed the 2021–22 and 2022–23 seasons with knee injuries.

At the age of 12, his stepfather, Jeffery, noticed Prather's athleticism and began teaching him the skills required to pursue playing professionally.

On November 17, 2009, he signed a National Letter of Intent to play college basketball for the University of Florida.

[3][4] As a senior in 2009–10, Prather was a finalist for Tennessee's Mr. Basketball after averaging 29 points, 13 rebounds, five blocks, five steals and three assists per game.

[5] During his time at North Side, Prather was member of the Nashville Celtics AAU team that captured the 2010 River City Showdown Championship.

[7] He became the third Gator under Billy Donovan to record three 27-point games in a single season, joining Nick Calathes (2008–09) and Teddy Dupay (2000–01).

[9][10] In the national semifinals, the Gators were defeated by Connecticut to fall short of reaching the championship game, despite a 15-point effort from Prather.

[22] On January 15, 2016, he scored a season-high 27 points in a 95–68 win over the Sydney Kings, helping the Wildcats snap a three-game losing streak.

[23] He helped the Wildcats reach the NBL Grand Final series,[24] where they defeated the New Zealand Breakers 2–1 to win the championship, with Prather scoring a team-high 19 points in game three.

In April 2017, Prather joined ratiopharm Ulm of the German Basketball Bundesliga for the rest of the 2016–17 season.

[47] Believing he was on the verge of joining the Cavaliers for the season, Prather rejected an offer to return to the Perth Wildcats.

[48] After failing to secure an NBA contract, Prather briefly turned his attention to Europe, before instead deciding to return to Australia.

[48] With Perth's roster full, Prather signed with Melbourne United for the 2017–18 NBL season on August 16.

[51] On December 16, he suffered a dislocated elbow in the second quarter of Melbourne's 84–78 win over the Illawarra Hawks.

[57][58] In game five, he recorded 19 points, 11 rebounds and five steals in a 100–82 win to help Melbourne clinch the championship with a 3–2 series victory.

[64][65] However, a clean-out of his knee resulted in his departure from Russia,[66] as he was replaced on the roster by Garlon Green in November[67][68] and was unable to make his debut for Khimki.

[69] On July 17, 2019, Prather signed a two-year deal with Melbourne United, returning to the team for a second stint.

[79] On August 20, 2020, Prather parted ways with United after mutually agreeing to terminate the second season of his contract.

[84] He helped Hapoel Eilat reach the semifinals, but sustained a knee injury during the dying seconds of the elimination match.

[89] On December 21, 2023, Prather signed a two-year deal with the Brisbane Bullets, returning to the Australian NBL for a fourth stint.

[97] He was subsequently named the Bullets Club MVP[98] and earned All-NBL Second Team honors.