The Antonio Mattei Lluberas Residence (Spanish: Residencia Antonio Mattei Lluberas), also known as La Casona Césari (Spanish for 'the Césari Manor') and the House of the Twelve Doors (La Casa de las Doce Puertas), is a historic late 19th-century manor house located in Yauco Pueblo, the administrative and historic center of the municipality of Yauco, Puerto Rico.

Its designer was architect Antonio Mattei Lluberas, after whom the house is often named, a rich landowner of Corsican and Catalan descent who studied architecture in Paris.

He later became famous for his opposition to the Spanish control of Puerto Rico and became an independence revolutionary leader in the failed 1896 and 1897 revolts in Guayanilla and Yauco, respectively.

He did not live in the house he designed, which instead became the property of another Corsican businessman - Ángel Césari Poggi and his wife, Angela Antongiorgi Rodríguez.

This Corsican-Puerto Rican family owned many acres of lands and properties throughout Yauco and southern Puerto Rico which they developed as sugarcane plantations, processing plants and refineries (centrales).