Cassandra is a borough in Cambria County, Pennsylvania, United States.

Cassandra is located in eastern Cambria County at 40°24′32″N 78°38′28″W / 40.40889°N 78.64111°W / 40.40889; -78.64111 (40.408989, -78.641040),[5] in the valley of the Little Conemaugh River.

According to the United States Census Bureau, Cassandra has a total area of 0.08 square miles (0.2 km2), all land.

Sewage Treatment in Cassandra Boro is provided by the Central Mainline Sewer Authority.

A dedication ceremony was held on August 21, 2006, by local congressman John Murtha.

Central-Mainline Serves over 2,000 customers and is named after the "Mainline" of the former Pennsylvania Railroad that proceed through the five municipalities.

Norfolk Southern operates on the former Pennsylvania Railroad mainline between Pittsburgh and Harrisburg.