Because of its religious significance and testimony to the lasting global effects of the Reformation, the church was inscribed on the UNESCO World Heritage List in 1996 along with other sites in Wittenberg and Eisleben associated with Martin Luther and Philip Melanchthon.

With further donations made by his successor Duke Rudolf II, it was determined the Wittenberg main church by Pope Boniface IX in 1400.

[8] [5] Extensive furnishings by Tilman Riemenschneider, Jacopo de' Barbari, and Albrecht Dürer contributed to the construction of the castle complex and then the church.

When during the Seven Years' War the Wittenberg fortress was occupied by the Prussian Army and shelled by Imperial forces in 1760, the Castle Church was destroyed by a fire resulting from the bombardment.

After Wittenberg was incorporated into the Prussian Province of Saxony, King Frederick William IV, in 1858, ordered commemorative bronze doors to be mounted onto the jambs where the original wooden ones had been located.

[9] On the occasion of the fourth centenary of Luther's birth in 1883, an extensive restoration of All Saints' in a Neo-Gothic style was begun under the supervision of the Prussian architect Friedrich Adler by his disciple Paul Ferdinand Groth (1859–1955).

A quote, "Ein feste Burg ist unser Gott" ("A Mighty Fortress Is Our God"), from one of Luther's hymns, encircles the tower.

These honored the most important Reformation students of Luther, and were created by Renate Brömme in a "timeless" style at the order of the Lutheran World Federation.

Today, All Saints' Church serves not only as a place of worship, but it also houses the town's historical archives, is home to the Riemer-Museum, and a youth hostel.

The church was festively reopened on 2 October 2016 in the presence of President Joachim Gauck and Margrethe II of Denmark, who dedicated an altar frontal designed by herself.