Along with Concatedral Dulce Nombre de Jesús or in English, the Co-cathedral Sweet Name of Jesus, in Humacao it is the seat of the Diocese of Fajardo-Humacao.

[3] It was listed on the National Register of Historic Places as Church Santiago Apóstol of Fajardo in 1984.

It became a cathedral church when Pope Benedict XVI established the Diocese of Fajardo-Humacao on March 11, 2008.

[6] It is located on the north side of the town plaza and is surrounded by a balustrade concrete wall with pillars that features metal grillwork gates.

The first bay includes the vestibule and features a spiral wooden staircase to the choir loft.