Jeremiah Tracey celebrated the first Mass in Sioux City in the log cabin of Mr. and Mrs. Louis Desy in 1855.

Timothy Treacy was the first pastor of the parish that was intended to serve the needs of a growing number of Irish and German immigrant Catholics in the central part of the city.

Today the parish continues to foster diversity as Masses are offered in English, Spanish, Vietnamese, and Latin.

[1] The most recent renovation project was in 1994 and addressed roofing, gutters, tuckpointing, and other exterior issues as well as restoring many of the interior elements and decoration that were removed in 1961.

[1] Des Moines architect Larry Ericsson of the restoration firm Wetherell-Ericsson was responsible for the designs that were meant to reflect the building's early 20th-century appearance.

The cathedral's sixty-one stained glass windows are from Franz Mayer & Co. in Munich, Germany, and were restored in the late 1980s.

[2] The reredos in the apse, the side altars, and Stations of the Cross are from the former St. Thomas Church in Emmetsburg, Iowa.

Rounding out the features are a slightly concave, straight pedalboard, combination action thumb pistons, combination action toe studs, coupler reversible thumb pistons, and coupler reversible toe studs.

The diocese held a fund drive and purchased three lots at the corner of Tenth and Douglas Streets for $40,500.

The Epiphany Center also houses the Cathedral Dual Language Academy for elementary students under the administration of Bishop Heelan Catholic Schools.