The church was designed by August Moszyński (for a long time it was mistakenly imputed to Jan de Witte).

As soon as the building was completed, then master of Ternopil, Polish magnate Józef Potocki handed the Church to the Dominican Order.

In particular, they built a new cupola, restored the original frescos and decorated the walls with new paintings, installed an organ and additional altars under the direction of the architect, Władysław Sadłowski.

On October 20–22, 1851, Emperor Franz Joseph I was in Ternopil in which a formal meeting was held in the Dominican Church of the city.

[3] It passed to the Greek-Catholic community of Ternopil and was renamed the Cathedral of the Immaculate Conception of the Blessed Virgin Mary.