[4] The original site of the school was an old frame building in downtown Baton Rouge, and the enrollment was 106 students.

In the 1930s and 1940s, the school's enrollment continued to increase, prompting the Brothers to acquire 10 acres (40,000 m2) of land in midtown Baton Rouge to build a campus to accommodate a larger student body, which was donated by R. Frank Cangelosi.

The 32,000 sf, two-story facility features a high-end commercial kitchen and dining for 600 downstairs as well as five classrooms, flexible study spaces, a conference room, and an expansive faculty wing on the second floor.

The goal of the new structure is to provide CHS student-athletes with a second workout location on campus to meet the current demand from the different sports teams.

[8] Catholic High has been recognized as a National Blue Ribbon School by the United States Department of Education 6 times: 1989, 1993, 1998, 2003, 2014, and 2020.

Catholic High school offers many sports to its students including football, swimming, wrestling, lacrosse, soccer, bowling, power lifting, ultimate frisbee, baseball, basketball, cross country, golf, tennis, and track and field.

In the 2024 season, the Bears, led by William Schmidt, were named national champions for the first time in school history.