While at University of Kentucky, DeBuono performed in a stage play directed by alumni student Ashley Judd.
Starting in 1997, DeBuono appeared in the last three seasons of Star Trek: Deep Space Nine as M'Pella, a dabo girl in Quark's bar.
[2] DeBuono also appeared as a background regular in several episodes of the television series Chicago Hope as a paramedic.
DeBuono was involved in the comedy series Jenny, The Pretender, Pacific Blue, Martial Law, Becker and Exes and Oh's.
[4] In the 2010s, DeBuono organized an effort to prevent convicted murderer Victor Paleologus from being paroled from prison.