After college, Guisewite followed her father's vocation and began working in advertising[1] at Campbell-Ewald, then Norman Prady, and settled at W.B.
[3] She continued to draw funny pictures as an "emotional coping mechanism" to events in her life and work, and she would forward them to her parents.
"[4] Guisewite was flabbergasted when the company sent her a contract to produce a comic strip.
So I believe the women I was speaking to in the early years of my strip were women like me, who were at that age in our 20s where we were kind of launched into adulthood with a foot in both worlds and no way to really express it.”[7] Guisewite appeared several times as a guest on the late night TV series The Tonight Show Starring Johnny Carson.
[6][9] In 1987, she received an Emmy Award for Outstanding Animated Program for the TV special Cathy.
[10] Guisewite adopted daughter Ivy in 1992, then married screenwriter Christopher Wilkinson in 1997.