It is divided among three counties for census purposes: A small cluster of Seneca-owned businesses are located along US 20 and NY 5 where they cross through the reservation.

Facilities include numerous cannabis dispensaries, a Bingo Hall, with a Poker Room and various video slot machines.

(At the reservation's southeast corner, near the village of Gowanda, it comes within a few feet of bordering the Town of Persia in Cattaraugus County.)

The reservation is mostly of a rural character, with one-family homes along Route 438 interspersed with businesses such as tobacco shops.

The reservation is divided into several communities such as Newtown, Bucktown, Pinewoods, Eleven Acres, Ozarks, and Indian Hill.