[7] It continues west, then makes a reverse curve to the southwest through the future Greenfield City Biñan development.

It approaches the first toll plaza near the Verdana Homes gated community and continues southwest, passing through a mix of developed and undeveloped areas at barangays Loma, Timbao and Malamig, then turning south into barangay Biñan, where it passes near Laguna Technopark, De La Salle University – Laguna Campus and several gated communities; access for them is provided by service roads.

The expressway partially runs above grade, utilizing underpass bridges, mechanically stabilized earth (MSE) walls, and a viaduct at this section to pass above major intersections and accesses.

Past the exit, it leaves the Nuvali Boulevard right of way and crosses the Silang–Santa Rosa River again, this time the Cavite–Laguna provincial boundary into Silang.

The expressway continues southwest and makes a few turns before traversing a bridge and entering a cut section, passing near South Forbes Golf City and Ayala Westgrove Heights.

JICA later conducted another study, this time on the master plan of the High Standard Highway Network (HSH) in 2010, which included the expressway project.

[22] According to a statement by MPCALA Holdings President Luigi Bautista, construction of the Cavite portion of the expressway was expected to begin in April 2018.

[24][25][26][27] Meanwhile, the Department of Public Works and Highways, then headed by Secretary Mark Villar, expected the Laguna segment to be opened by October 2019.

[35] The expressway was closed from January 28 to 31 and February 4 to 7, 2020, from 1:00 AM to 4:00 AM (PST) to give way for construction and clearing operations due to ashfalls brought on by the 2020 Taal Volcano eruption.

[42] Cavite–Laguna Expressway is a closed road system in which motorists pay a toll based on their vehicle class and distance travelled.