Viewed from an isometric perspective, the game requires interactions with computers, combining items and puzzle solving.

The game centers around the main character John Maracheck who awakes from Stasis aboard an abandoned spaceship.

Exploring the ship he learns that it is a medical frigate run by the Cayne Corporation for illegal research on unwilling victims.

From a variety of PDAs he learns that senior scientist Dr. Malan created project SEED, designed to create supersoldiers by reactivating dormant human genes through torturous experimentation and forced impregnations, resulting in the creation of animalistic and vicious mutant humans referred to as 'hybrids'.

Reaching the escape deck, John shatters a portal and vents Dr. Malan into space, before falling and breaking his leg.

The game adopts the classic point-and-click system to allow interactions with the environment and utilises PDA data to help unravel aspects of the story.

[6][7] In an interview with IGN, Stasis creator Chris Bischoff cited elements from films Alien and Event Horizon, as well as Dead Space, as inspirations for the work.