Cayo Saetía (also spelled Sae-Tía) is a 42 km2 (16 sq mi) cay (island) in Holguín Province, Cuba.

[2] It is located 120 km (75 mi) southeast of Holguín between the Bay of Nipe & the Atlantic Ocean.

Once a private government game reserve, it now houses a resort managed by the Grupo de Turismo Gaviota, S.A. and a Cuban Youth camp.

It has been stocked with zebra, water buffalo, boar and various antelope and deer species which roam freely on the cay.

Resorts in the Guardalavaca tourist area offer helicopter and boat tours to the cayo for safaris and its white sand beaches.