Cayuga is a town in Eugene Township, Vermillion County, in the U.S. state of Indiana.

[6] It was later renamed after the village of Cayuga and Cayuga Lake in the state of New York; an early settler named John Groenendyke had originally come from Cayuga County, New York, and moved to Vigo County in 1818, then in 1819 moved to the area that later became Vermillion County.

Local legend attributes the name to the sound made by the horn of a Ford Model T.[7] The town was incorporated around 1891.

[9] Cayuga is located at the intersection of Indiana State Road 63 and Indiana State Road 234, in the northern half of the county, near the confluence of the Vermillion and Wabash rivers.

According to the 2010 census, Cayuga has a total area of 1.01 square miles (2.62 km2), all land.

26.7% of all households were made up of individuals, and 14.9% had someone living alone who was 65 years of age or older.

30.3% of all households were made up of individuals, and 19.1% had someone living alone who was 65 years of age or older.