The front facade features a monumental Greek Revival pedimented portico with massive fluted Ionic columns.
The interior features a rare example of a Tiffany Glass and Decorating Company domestic window added about 1894–1896.
Ted Case was an American physicist and inventor known for the invention of the Movietone optical sound-on-film method for sound films ("talkies").
The property now houses the Cayuga Museum of History and Art and Case Research Lab.
The Dr. Sylvester Willard Mansion was listed on the National Register of Historic Places in 1989.