In May 2020, she began appearing in a prime time ABC television series called The Genetic Detective in which each episode recounts a cold case she helped solve.

[2] In addition to her television work, she is known for pioneering the genetic genealogy methodologies used by adoptees and others of unknown origin for identifying biological family.

Moore became fascinated by the subject, taught herself about it, passed over her business projects to her husband Lennart Martinson and worked full-time on DNA genealogy.

In 2012 - 2014, she was the genetic genealogist who worked with the Branum family on the Thomas Ray Lippert University of Utah artificial insemination sperm swap case.

[17][18][19][20] Paul Fronczak was a newborn who was kidnapped from his mother's arms by a woman posing as a nurse in a Chicago hospital in 1964 and believed to have been returned to his natural parents in 1966.

[24] In 2015, Moore led a team of researchers that established the true identity of amnesiac Benjaman Kyle as William Burgess Powell.

[30] As the genetic genealogist for the PBS series Finding Your Roots with Henry Louis Gates, Jr., in 2015 Moore made the discovery that LL Cool J's mother was adopted.