The Florida Army National Guard's primary Army Aviation Support Facility and the U.S. Coast Guard's Helicopter Interdiction Tactical Squadron (HITRON) are also located here, the former operating CH-47 Chinook, UH-60 Blackhawk, UH-72 Lakota and C-12 Huron aircraft, and the latter operating the MH-65C Dolphin helicopter.

Fire Station 73 (under construction) will be located on the airfield as well and will include ARFF, structural and rescue (ambulance) protection.

[2] In 2010, Cecil Airport became the United States' eighth licensed commercial spaceport and the first in Florida authorized to fly space vehicles that take off and land horizontally.

The airport is located on the site of the former Naval Air Station Cecil Field, which opened in 1941 and closed in 1999 following the 1993 Base Realignment and Closure Commission decision.

[4] Cecil Airport covers an area of 6,082 acres (24.61 km2) and contains four runways and two helipads:[1] For the 12-month period ending February 5, 2018, the airport had 104,361 aircraft operations, an average of 286 per day: 52% military (53,899), 47% general aviation (49,372), <1% air carrier (744) and <1% air taxi (346).