María Cecilia Arboleda de Holguín (née: Arboleda Mosquera; 21 January 1859 - 3 February 1924), was a Colombian socialite, wife of the 10th President of Colombia, Jorge Holguín.

Arboleda de Holguín served as First Lady of Colombia from 1921 to 1922.

On 9 August 1877, she married the conservative politician from Cauca Jorge Holguín, who would later become the 10th President of Colombia.

On 11 November 1921, the resignation of the 9th President of Colombia, Marco Fidel Suárez, was officially presented, which made Jorge Holguín the 10th president of Colombia, being the next in line and one of the men of maximum confidence of Marco Fidel Suárez, making Cecilia the new first lady of Colombia, a position she held until 7 August 1922.

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